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Shb (phospho Tyr246) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60245

  • Amount:

    100ul

  • Molecular Weight:

    55042Da

  • Applications:

    WB;IHC-p

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    Synthesized phospho-peptide around the phosphorylation site of human Shb (phospho Tyr246)

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Phospho-Shb (Y246) Polyclonal Antibody

  • Gene Name:

    SHB

  • Dilution:

    WB 1:500-2000;IHC-p 1:50-300

  • Background:

    domain:The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.,function:Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.,PTM:Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGRF1 or VEGFR2 activation.,similarity:Contains 1 SH2 domain.,subcellular location:Associates with membrane lipid rafts upon TCR stimulation.,subunit:Interacts with PTPN11 (By similarity). Interacts with phosphorylated 'Tyr-720' of the ligand-activated receptor PDGFRA via its SH2 domain. Interacts with the ligand-activated receptors PDGFRB, FGFR1, KDR/VEGFR2, IL2RB and IL2RG. Interacts with EPS8 and V-SRC. Interacts with GRB2 and GRAP. Interacts with CD3Z. Interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor activation. Interacts with PLCG1. Interacts with ZAP70, LCP2/SLP-76, VAV1 and GRAP2. Interacts with JAK1 and JAK3. Interacts with PTK2/FAK1. Interacts with CRK/CrKII. Interacts with IRS2.,tissue specificity:Widely expressed.,

  • Protein Name:

    SH2 domain-containing adapter protein B

  • Human Gene Id:

    6461

  • Human Swiss Prot No:

    Q15464

  • Mouse Gene Id:

    230126

  • Mouse Swiss Prot No:

    Q6PD21

  • Specificity:

    Phospho-Shb (Y246) Polyclonal Antibody detects endogenous levels of Shb protein only when phosphorylated at Y246.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    SHB; SH2 domain-containing adapter protein B

  • Observed Band(KD):

    55

  • Function:

    domain:The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.,function:Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.,PTM:Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGRF1 or VEGFR2 activation.,similarity:Contains 1 SH2 domain.,subcellular location:Associates with membrane lipid rafts upon TCR stimulation.,subunit:Interacts with P

  • Subcellular Location:

    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Associates with membrane lipid rafts upon TCR stimulation.

  • Expression:

    Widely expressed.

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Catalog Number

  • Amount:100ul
  • Price:225$

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Shb (phospho Tyr246) Polyclonal Antibody | EnoGene Biotech Co. Ltd