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Neu (phospho Tyr1248) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60178

  • Amount:

    100ul

  • Molecular Weight:

    137910(DA) Observed Band(KD)180

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human HER2 around the phosphorylation site of Tyr1248. AA range:1206-1255

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of 293 cells using Phospho-Neu (Y1248) Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    ERBB2

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Receptor tyrosine-protein kinase erbB-2

  • Human Gene Id:

    2064

  • Human Swiss Prot No:

    P04626

  • Mouse Gene Id:

    13866

  • Mouse Swiss Prot No:

    P70424

  • Rat Swiss Prot No:

    P06494

  • Specificity:

    Phospho-Neu (Y1248) Polyclonal Antibody detects endogenous levels of Neu protein only when phosphorylated at Y1248.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340

  • Background:

    erb-b2 receptor tyrosine kinase 2(ERBB2) Homo sapiens This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in ERBB2 are associated with familial glioma of brain [MIM:137800]; also called glioblastoma multiforme. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas.,disease:Defects in ERBB2 are associated with gastric cancer [MIM:137215]; also known as hereditary familial diffuse gastric cancer (HDGC).,disease:Defects in ERBB2 are associated with lung cancer [MIM:211980]; also called adenocarcinoma of lung.,disease:Defects in ERBB2 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of viscera

  • Subcellular Location:

    nucleus,cytoplasm,plasma membrane,endosome membrane,membrane,integral component of membrane,basolateral plasma membrane,apical plasma membrane,cytoplasmic vesicle,myelin sheath,receptor complex,perinuclear region

  • Expression:

    Epithelium,Lung,Mammary carcinoma,Placenta,

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Catalog Number

  • Amount:100ul
  • Price:225$

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Neu (phospho Tyr1248) Polyclonal Antibody | EnoGene Biotech Co. Ltd