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MEK-4 (phospho Ser80) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60171

  • Amount:

    100ul

  • Molecular Weight:

    44288Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human SEK1/MKK4 around the phosphorylation site of Ser80. AA range:46-95

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Phospho-MEK-4 (S80) Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    MAP2K4

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Background:

    This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

  • Protein Name:

    Dual specificity mitogen-activated protein kinase kinase 4

  • Human Gene Id:

    6416

  • Human Swiss Prot No:

    P45985

  • Mouse Gene Id:

    26398

  • Mouse Swiss Prot No:

    P47809

  • Specificity:

    Phospho-MEK-4 (S80) Polyclonal Antibody detects endogenous levels of MEK-4 protein only when phosphorylated at S80.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro

  • Observed Band(KD):

    44

  • Function:

    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).,PTM:Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with SPAG9.,tissue specificity:Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.,

  • Subcellular Location:

    Cytoplasm . Nucleus .

  • Expression:

    Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using SEK1/MKK4 (Phospho-Ser80) Antibody. The picture on the right is blocked with the phospho peptide.

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