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MEF-2 (phospho Thr312) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60163

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MEF2A around the phosphorylation site of Thr312. AA range:279-328

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    MEF2A

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/20000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using MEF2A (Phospho-Thr312) Antibody. The picture on the right is blocked with the phospho peptide.

  • Background:

    myocyte enhancer factor 2A(MEF2A) Homo sapiens The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010],

  • Protein Name:

    Myocyte-specific enhancer factor 2A

  • Human Gene Id:

    4205

  • Human Swiss Prot No:

    Q02078

  • Mouse Gene Id:

    17258

  • Mouse Swiss Prot No:

    Q60929

  • Rat Gene Id:

    309957

  • Rat Swiss Prot No:

    Q2MJT0

  • Specificity:

    Phospho-MEF-2 (T312) Polyclonal Antibody detects endogenous levels of MEF-2 protein only when phosphorylated at T312.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MEF2A; MEF2; Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1

  • MolecularWeight(Da):

    54811

  • Function:

    disease:Defects in MEF2A might be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1) [MIM:608320].,function:Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.,PTM:Acetylation on Lys-403 activates transcriptional activity. Acetylated by p300 on several sites in di

  • Subcellular Location:

    nuclear chromatin,nucleus,nucleoplasm,transcription factor complex,cytoplasm,

  • Expression:

    Amygdala,Brain,Heart,Pancreas,Placenta,Skeletal muscle,Uterus,

  • Western blot analysis of lysates from NIH/3T3 cells treated with PMA, using MEF2A (Phospho-Thr312) Antibody. The lane on the left is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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MEF-2 (phospho Thr312) Polyclonal Antibody | EnoGene Biotech Co. Ltd