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IRS-1 (phospho Ser636) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60148

  • Amount:

    100ul

  • Molecular Weight:

    131591Da

  • Applications:

    WB;IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human IRS-1 around the phosphorylation site of Ser636. AA range:603-652

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Phospho-IRS-1 (S636) Polyclonal Antibody diluted at 1:2000

  • Gene Name:

    IRS1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

  • Background:

    This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009],

  • Protein Name:

    Insulin receptor substrate 1

  • Human Gene Id:

    3667

  • Human Swiss Prot No:

    P35568

  • Mouse Gene Id:

    16367

  • Mouse Swiss Prot No:

    P35569

  • Rat Gene Id:

    25467

  • Rat Swiss Prot No:

    P35570

  • Specificity:

    Phospho-IRS-1 (S636) Polyclonal Antibody detects endogenous levels of IRS-1 protein only when phosphorylated at S636.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    IRS1; Insulin receptor substrate 1; IRS-1

  • Observed Band(KD):

    170

  • Function:

    disease:Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].,function:May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.,polymorphism:The Arg-971 polymorphism impairs the ability of insulin to stimulate glucose transport, glucose transporter translocation, and glycogen synthesis by affecting the PI3K/AKT1/GSK3 signaling pathway. The polymorphism at Arg-971 may contribute to the in vivo insulin resistance observed in carriers of this variant. Arg-971 could contribute to the risk for atherosclerotic cardiovascular diseases associated with non-insulin-dependen

  • Subcellular Location:

    nucleus,cytoplasm,cytosol,plasma membrane,insulin receptor complex,caveola,intracellular membrane-bounded organelle,

  • Expression:

    Epithelium,Eye,Skeletal muscle,

  • Western Blot analysis of SH-SY5Y cells using Phospho-IRS-1 (S636) Polyclonal Antibody diluted at 1:2000

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Catalog Number

  • Amount:100ul
  • Price:225$

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IRS-1 (phospho Ser636) Polyclonal Antibody | EnoGene Biotech Co. Ltd