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Integrin β3 (phospho Tyr773) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60144

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Integrin beta3 around the phosphorylation site of Tyr773. AA range:739-788

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ITGB3

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Integrin beta3 (Phospho-Tyr773) Antibody. The picture on the right is blocked with the phospho peptide.

  • Background:

    integrin subunit beta 3(ITGB3) Homo sapiens The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Integrin beta-3

  • Human Gene Id:

    3690

  • Human Swiss Prot No:

    P05106

  • Mouse Gene Id:

    16416

  • Mouse Swiss Prot No:

    O54890

  • Specificity:

    Phospho-Integrin β3 (Y773) Polyclonal Antibody detects endogenous levels of Integrin β3 protein only when phosphorylated at Y773.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ITGB3; GP3A; Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD antigen CD61

  • MolecularWeight(Da):

    87214

  • Observed Band(KD):

    130

  • Function:

    disease:Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors.,function:Int

  • Subcellular Location:

    nucleus,plasma membrane,integral component of plasma membrane,focal adhesion,integrin complex,cell surface,integral component of membrane,platelet alpha granule membrane,lamellipodium membrane,filopodium membrane,microvillus membrane,

  • Expression:

    Blood,Erythroleukemia,Keratinocyte,Liver,Osteoclastoma,Placenta,Plasma,Platelet,Ske

  • Western blot analysis of lysates from HL-60 cells treated with H2O2, using Integrin beta3 (Phospho-Tyr773) Antibody. The lane on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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Integrin β3 (phospho Tyr773) Polyclonal Antibody | EnoGene Biotech Co. Ltd