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ICAM-1 (phospho Tyr512) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60137

  • Amount:

    100ul

  • Molecular Weight:

    57825Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Rat;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ICAM-1 around the phosphorylation site of Tyr512. AA range:479-528

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Phospho-ICAM-1 (Y512) Polyclonal Antibody diluted at 1:500

  • Gene Name:

    ICAM1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

  • Background:

    This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Intercellular adhesion molecule 1

  • Human Gene Id:

    3383

  • Human Swiss Prot No:

    P05362

  • Mouse Swiss Prot No:

    P13597

  • Specificity:

    Phospho-ICAM-1 (Y512) Polyclonal Antibody detects endogenous levels of ICAM-1 protein only when phosphorylated at Y512.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ICAM1; Intercellular adhesion molecule 1; ICAM-1; Major group rhinovirus receptor; CD antigen CD54

  • Observed Band(KD):

    57

  • Function:

    function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell a

  • Subcellular Location:

    Membrane; Single-pass type I membrane protein.

  • Expression:

    Blood,Kidney,Liver,Melanoma,Plasma,

  • Western blot analysis of lysates from HeLa cells treated with TNF-alpha 20ng/ml 5', using ICAM-1 (Phospho-Tyr512) Antibody. The lane on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
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ICAM-1 (phospho Tyr512) Polyclonal Antibody | EnoGene Biotech Co. Ltd