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GATA-1 (phospho Ser310) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60120

  • Amount:

    100ul

  • Molecular Weight:

    42751Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse;Rat;Monkey

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GATA1 around the phosphorylation site of Ser310. AA range:277-326

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Phospho-GATA-1 (S310) Polyclonal Antibody diluted at 1:500 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).

  • Gene Name:

    GATA1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

  • Background:

    This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Erythroid transcription factor

  • Human Gene Id:

    2623

  • Human Swiss Prot No:

    P15976

  • Mouse Gene Id:

    14460

  • Mouse Swiss Prot No:

    P17679

  • Rat Gene Id:

    1.00911e+008

  • Rat Swiss Prot No:

    P43429

  • Specificity:

    Phospho-GATA-1 (S310) Polyclonal Antibody detects endogenous levels of GATA-1 protein only when phosphorylated at S310.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    GATA1; ERYF1; GF1; Erythroid transcription factor; Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein

  • Function:

    disease:Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.,disease:Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]; also called thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. The disease consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor.,domain:The two fingers are functionally distinct and cooperate to achie

  • Subcellular Location:

    Nucleus.

  • Expression:

    Erythrocytes.

  • Western blot analysis of lysates from COS7 cells treated with EPO, using GATA1 (Phospho-Ser310) Antibody. The lane on the left is blocked with the phospho peptide.

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GATA-1 (phospho Ser310) Polyclonal Antibody | EnoGene Biotech Co. Ltd