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Gab 1 (phospho Tyr627) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60118

  • Amount:

    100ul

  • Molecular Weight:

    76616Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse;Monkey

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human GAB1 around the phosphorylation site of Tyr627 AA range:611-643

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Phospho-Gab 1 (Y627) Polyclonal Antibody

  • Gene Name:

    GAB1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Background:

    GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],

  • Protein Name:

    GRB2-associated-binding protein 1

  • Human Gene Id:

    2549

  • Human Swiss Prot No:

    Q13480

  • Mouse Gene Id:

    14388

  • Mouse Swiss Prot No:

    Q9QYY0

  • Specificity:

    Phospho-Gab 1 (Y627) Polyclonal Antibody detects endogenous levels of Gab 1 protein only when phosphorylated at Y627.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    GAB1; GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1

  • Observed Band(KD):

    110

  • Function:

    function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.,

  • Subcellular Location:

    cytosol,

  • Expression:

    Testis,Whole embryo,

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using GAB1 (Phospho-Tyr627) Antibody

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Catalog Number

  • Amount:100ul
  • Price:225$

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Gab 1 (phospho Tyr627) Polyclonal Antibody | EnoGene Biotech Co. Ltd