E20-60083
Datasheet
Catalog Number:
E20-60083Amount:
100ulMolecular Weight:
22963DaApplications:
WB;IHC-p;IF(paraffin section);ELISAReactivity:
Human;Mouse;Rat;MonkeyPurification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human DARPP-32 around the phosphorylation site of Thr75. AA range:41-90Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using Phospho-DARPP-32 (T75) Polyclonal Antibody diluted at 1:500
Gene Name:
PPP1R1BDilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.Background:
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],Protein Name:
Protein phosphatase 1 regulatory subunit 1BHuman Gene Id:
84152Human Swiss Prot No:
Q9UD71Mouse Gene Id:
19049Mouse Swiss Prot No:
Q60829Rat Gene Id:
360616Rat Swiss Prot No:
Q6J4I0Specificity:
Phospho-DARPP-32 (T75) Polyclonal Antibody detects endogenous levels of DARPP-32 protein only when phosphorylated at T75.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
PPP1R1B; DARPP32; Protein phosphatase 1 regulatory subunit 1B; DARPP-32; Dopamine- and cAMP-regulated neuronal phosphoproteinObserved Band(KD):
32Function:
function:Inhibitor of protein-phosphatase 1.,PTM:Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.,PTM:Phosphorylation of Thr-34 is required for activity.,similarity:Belongs to the protein phosphatase inhibitor 1 family.,Subcellular Location:
Cytoplasm.Expression:
Adipose tissue,Brain,Cerebellum,Colon,Ovary,
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