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AP-1 (phospho Tyr170) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60018

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human c-Jun around the phosphorylation site of Tyr170. AA range:137-186

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    JUN

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Western blot analysis of lysates from HeLa cells treated with UV, using c-Jun (Phospho-Tyr170) Antibody. The lane on the left is blocked with the phospho peptide.

  • Background:

    Jun proto-oncogene, AP-1 transcription factor subunit(JUN) Homo sapiens This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Transcription factor AP-1

  • Human Gene Id:

    3725

  • Human Swiss Prot No:

    P05412

  • Mouse Gene Id:

    16476

  • Mouse Swiss Prot No:

    P05627

  • Rat Gene Id:

    24516

  • Rat Swiss Prot No:

    P17325

  • Specificity:

    Phospho-AP-1 (Y170) Polyclonal Antibody detects endogenous levels of AP-1 protein only when phosphorylated at Y170.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    JUN; Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39

  • MolecularWeight(Da):

    35676

  • Observed Band(KD):

    39-42

  • Function:

    function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.,PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.,

  • Subcellular Location:

    nuclear chromosome,nucleus,nucleoplasm,transcription factor complex,nuclear euchromatin,cytosol,transcriptional repressor complex,

  • Expression:

    B-cell,Epithelium,Ovary,Testis,Uterus,

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Catalog Number

  • Amount:100ul
  • Price:225$

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AP-1 (phospho Tyr170) Polyclonal Antibody | EnoGene Biotech Co. Ltd