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HSC70 Monoclonal Antibody
,Human,Rat,Mouse
WB,IHC-p
Mouse
Price on request
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Form Or Antibody
Form of Antibodyname:HSC70 Monoclonal Antibody
Gene NameHSPA8Protein Name:Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)
Human Gene Id:3312
Human Swiss Prot No:P11142
Mouse Swiss Prot No:P63017
Rat Swiss Prot No:P63018
Human Gene Id:3312
Human Swiss Prot No:P11142
Mouse Swiss Prot No:P63017
Rat Swiss Prot No:P63018
ImmunogenSynthesized peptide derived from the Internal region of human HSC 70.
Specificty Sensitivity
Specificity/SensitivityThe antibody detects endogenous HSC70 protein
Product Information
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
DilutionWestern Blot: 1/500 - 1/2000.IHC-p:1:50-300. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
Storage/StabilityStability:-20°C/1 year
Other NamesHeat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)Observed Band(KD):70
Backgroundheat shock protein family A (Hsp70) member 8(HSPA8) Homo sapiens This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].Function:function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous.
Cellular localizationubiquitin ligase complex,Prp19 complex,extracellular space, intracellular, nucleus, nucleoplasm, spliceosomal complex,nucleolus,lysosomal membrane,late endosome,cytosol,plasma membrane.Expression:Bone marrow,Brain,Cajal-Retzius cell,Cerebellum.
Western blot analysis of 1)Hela, 2)Mouse Brain Tissue, 3) Rat Brain Tissue with HSC70 Mouse mAb diluted at 1:2,000.
Immunohistochemical analysis of paraffin- embedded Human Breast Carcinoma using HSC70 Mouse mAb diluted at 1:200.
Conjugated Antibody
This product is also available conjugated. Format: E20-53597-Conjugate. Price: $485 / Size: 100μl.
E20-53597-FITC$485 / 100μlE20-53597-Biotin$485 / 100μlE20-53597-HRP$485 / 100μlE20-53597-AP$485 / 100μlE20-53597-AF350$485 / 100μlE20-53597-AF405M$485 / 100μlE20-53597-AF488$485 / 100μlE20-53597-AF514$485 / 100μlE20-53597-AF532$485 / 100μlE20-53597-AF555$485 / 100μlE20-53597-AF568$485 / 100μlE20-53597-AF405S$485 / 100μlE20-53597-AF405L$485 / 100μlE20-53597-AF546$485 / 100μlE20-53597-AF594$485 / 100μlE20-53597-AF610$485 / 100μlE20-53597-AF635$485 / 100μlE20-53597-AF647$485 / 100μlE20-53597-AF680$485 / 100μlE20-53597-AF700$485 / 100μlE20-53597-AF750$485 / 100μlE20-53597-AF790$485 / 100μlE20-53597-APC$485 / 100μlE20-53597-PE$485 / 100μlE20-53597-Cy3$485 / 100μlE20-53597-Cy5$485 / 100μlE20-53597-Cy5.5$485 / 100μlE20-53597-Cy7$485 / 100μlE20-53597-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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