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Histone H2A (Acetyl Lys15) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-53298

  • Amount:

    100ul

  • Molecular Weight:

    14091/14095/14121Da

  • Applications:

    WB

  • Reactivity:

    Human;Mouse;RatFields:>>Necroptosis;>>Neutrophil extracellular trap formation;>>Alcoholism;>>Systemic lupus erythematosus
    GeneName:HIST1H2AG/HIST1H2AI/HIST1H2AK/HIST1H2AL/HIST1H2AM/HIST2H2AA3/HIST2H2AA4/HIST3H2A

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.

  • Immunogen:

    Synthetic Peptide of Histone H2A (Acetyl Lys15)

  • Source:

    Polyclonal, Rabbit,IgG

  • Western blot analysis of extracts from Hela cells, untreated (-) or treated, 1:5000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000

  • Dilution:

    WB: 1:500-1000

  • Background:

    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015],

  • Protein Name:

    Histone H2A type 1/Histone H2A type 2/Histone H2A type 3

  • Specificity:

    The antibody detects endogenous Histone H2A (Acetyl Lys15) protein.

  • Formulation:

    PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

  • Human Gene Id:

    8329/8330/8332/8336/8969/723790/8337/92815

  • Mouse Gene Id:

    319164/15267/319162

  • Rat Gene Id:

    365877/64646

  • Human Swiss Prot No:

    P0C0S8/Q6FI13/Q7L7L0

  • Rat Swiss Prot No:

    P02262/P0CC09/Q4FZT6

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    HIST1H2AG; H2AFP; HIST1H2AI; H2AFC; HIST1H2AK; H2AFD; HIST1H2AL; H2AFI; HIST1H2AM; H2AFN; Histone H2A type 1; H2A.1; Histone H2A/p; HIST2H2AA3; H2AFO; HIST2H2AA; HIST2H2AA4; Histone H2A type 2-A; Histone H2A.2; Histone H2A/o; HIST3H2A; Histone H2A type 3;H2AK15AC; YM3298

  • Observed Band(KD):

    14

  • Function:

    function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,PTM:Deiminated on Arg-4 in granulocytes upon calcium entry.,PTM:Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosom

  • Subcellular Location:

    Nucleus. Chromosome.

  • Expression:

    Bone,Brain,Colon,Eye,Lymph,PCR rescued clones,Placenta,Sple

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Catalog Number

  • Amount:100ul
  • Price:225$

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Histone H2A (Acetyl Lys15) Polyclonal Antibody | EnoGene Biotech Co. Ltd