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Cytokeratin 6 Monoclonal Antibody(4A1)
Datasheet   

  • Catalog Number:

    E20-53080

  • Amount:

    100ul

  • Applications:

    WB;IHC-p;IF/ICC;

  • Reactivity:

    Human;

  • Purification:

    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

  • Immunogen:

    Synthetic Peptide of Cytokeratin 6

  • Source:

    Monoclonal, Mouse

  • Immunohistochemical analysis of paraffin-embedded Human-breast-cancer tissue. 1,CytokeRatin 6 Monoclonal Antibody(4A1) was diluted at 1:200(4°C,overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval(>98°C,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min). Negative control was used by secondary antibody only.

  • Gene Name:

    KRT6A/B/C

  • Dilution:

    WB: 1:1000 IF 1:200 IHC 1:50-300

  • Background:

    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathoge

  • Protein Name:

    Keratin type II cytoskeletal 6A/B/C

  • Human Gene Id:

    3854/286887/3853

  • Human Swiss Prot No:

    P02538/P04259/P48668

  • Specificity:

    The antibody detects endogenous Cytokeratin 6 proteins.

  • Formulation:

    PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

  • Storage Stability:

    -20°C/1 yearObserved Band:56-60KD

  • Function:

    allergen:Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.,disease:Defects in KRT6A are a cause of pachyonychia congenita type 1 (PC1) [MIM:167200]; also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.,miscellaneous:There are at least six isoforms of human type II keratin-6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and

  • Subcellular Location:

    nucleus,intermediate filament,membrane,keratin filament,extracellular exosome,

  • Expression:

    Expressed in the corneal epithelium (at protein level).

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Catalog Number

  • Amount:100ul
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Cytokeratin 6 Monoclonal Antibody(4A1) | EnoGene Biotech Co. Ltd