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CD10 Monoclonal Antibody
Datasheet   

  • Catalog Number:

    E20-53072

  • Amount:

    100ul

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;

  • Purification:

    Affinity purification

  • Immunogen:

    Purified recombinant fragment of CD10 expressed in E. Coli.

  • Source:

    Monoclonal, Mouse

  • Gene Name:

    MME

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

  • Western Blot analysis using CD10 Monoclonal Antibody against truncated CD10-His recombinant protein (1).

  • Background:

    This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this

  • Protein Name:

    Neprilysin

  • Human Gene Id:

    4311

  • Human Swiss Prot No:

    P08473

  • Mouse Swiss Prot No:

    Q61391

  • Specificity:

    CD10 Monoclonal Antibody detects endogenous levels of CD10 protein.

  • Formulation:

    Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD antigen CD10

  • References:

    1. Journal of Gastroenterology,1996 Feb.31(1):12-7.  2. British Journal of Haematology,1995,89(3):623-6.

  • Function:

    catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,disease:Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.,enzyme regulation:Inhibited in a dose dependent manner by opiorphin.,function:Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).,similarity:Belongs to the peptidase M13 family.,

  • Subcellular Location:

    Cell membrane; Single-pass type II membrane protein.

  • Expression:

    Adrenal cortex,Brain,Kidney,Placenta,

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Catalog Number

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CD10 Monoclonal Antibody | EnoGene Biotech Co. Ltd