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Ki 67 Monoclonal Antibody(4A8)
Datasheet   

  • Catalog Number:

    E20-53064

  • Amount:

    100ul

  • Molecular Weight:

    358694Da

  • Applications:

    IHC-P;IF/ICC

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

  • Immunogen:

    Synthetic Peptide of Ki 67

  • Source:

    Monoclonal, Mouse

  • Zhang, B., Miao, T., Shen, X. et al. EB virus-induced ATR activation accelerates nasopharyngeal carcinoma growth via M2-type macrophages polarization. Cell Death Dis11, 742 (2020).

  • Gene Name:

    MKI67

  • Dilution:

    IHC 1:200 IF 1:50-200

  • Background:

    This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009],

  • Protein Name:

    Antigen KI-67

  • Human Gene Id:

    4288

  • Human Swiss Prot No:

    P46013

  • Specificity:

    The antibody detects endogenous Ki 67 proteins.

  • Formulation:

    PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MKI67; Antigen KI-67

  • Function:

    developmental stage:Expression of this antigen occurs preferentially during late G1, S, G2 and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected.,function:Thought to be required for maintaining cell proliferation.,online information:Ki-67 entry,similarity:Contains 1 FHA domain.,subcellular location:Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.,subunit:Interacts with KIF15. Binds through the FHA domain to MKI67IP.,

  • Subcellular Location:

    Chromosome . Nucleus . Nucleus, nucleolus . Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106). .

  • Expression:

    Epithelium,

  • Chuangxin Lin, et al."Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12". Bone Research (2019) 7:5

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Catalog Number

  • Amount:100ul
  • Price:225$

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Ki 67 Monoclonal Antibody(4A8) | EnoGene Biotech Co. Ltd