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Carcinoembryonic Antigen Monoclonal Antibody(10E1)
Datasheet   

  • Catalog Number:

    E20-53061

  • Amount:

    100ul

  • Applications:

    IHC-P;IF/ICC

  • Reactivity:

    Human

  • Purification:

    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

  • Immunogen:

    Synthetic Peptide of Carcinoembryonic Antigen

  • Source:

    Monoclonal, Mouse

  • Immunohistochemical analysis of paraffin-embedded Human-liver tissue. 1,Carcinoembryonic Antigen Monoclonal Antibody(10E1) was diluted at 1:200(4°C,overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval(>98°C,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min). Negative control was used by secondary antibody only.

  • Gene Name:

    CEACAM5

  • Dilution:

    WB 500-2000 1:200 IF 1:50-200

  • Background:

    This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],

  • Protein Name:

    Carcinoembryonic antigen-related cell adhesion molecule 5

  • Human Gene Id:

    1048

  • Human Swiss Prot No:

    P06731

  • Mouse Gene Id:

    73250

  • Mouse Swiss Prot No:

    Q3UKK2

  • Specificity:

    The antibody detects endogenous CEA proteins.

  • Formulation:

    PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CEACAM5; CEA; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e

  • Observed Band(KD):

    113

  • Function:

    function:Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.,PTM:Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.,similarity:Belongs to the immunoglobulin superfamily. CEA family.,similarity:Contains 7 Ig-like (immunoglobulin-like) domains.,subunit:Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.,tissue specificity:Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.,

  • Subcellular Location:

    Cell membrane ; Lipid-anchor, GPI-anchor . Apical cell membrane . Cell surface . Localized to the apical glycocalyx surface. .

  • Expression:

    Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

  • Immunofluorescence analysis of Human-lung-cancer tissue. 1,Carcinoembryonic Antigen Monoclonal Antibody(10E1)(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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Catalog Number

  • Amount:100ul
  • Price:225$

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Carcinoembryonic Antigen Monoclonal Antibody(10E1) | EnoGene Biotech Co. Ltd