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GFAP Monoclonal Antibody(5C8)
Datasheet   

  • Catalog Number:

    E20-53059

  • Amount:

    100ul

  • Applications:

    WB;IHC-p;IF/ICC;

  • Reactivity:

    Human;Rat;Mouse

  • Purification:

    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

  • Immunogen:

    Synthetic Peptide of GFAP

  • Source:

    Monoclonal, Mouse

  • Wang, Hao, et al. "Effects of altitude changes on mild‑to‑moderate closed‑head injury in rats following acute high‑altitude exposure." Experimental and therapeutic medicine 17.1 (2019): 847-856.

  • Gene Name:

    GFAP

  • Dilution:

    WB: 1:2000-5000 IF 1:200 IHC 1:50-300

  • Background:

    This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],

  • Protein Name:

    Glial fibrillary acidic protein

  • Human Gene Id:

    2670

  • Human Swiss Prot No:

    P14136

  • Mouse Gene Id:

    14580

  • Mouse Swiss Prot No:

    P03995

  • Rat Gene Id:

    24387

  • Rat Swiss Prot No:

    P47819

  • Specificity:

    The antibody detects endogenous GFAP proteins.

  • Formulation:

    PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    GFAP; Glial fibrillary acidic protein; GFAP

  • Observed Band(KD):

    45

  • Function:

    alternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons,disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.,function:GFAP, a class-III intermediate filament, is a cell-spe

  • Subcellular Location:

    Cytoplasm . Associated with intermediate filaments. .

  • Expression:

    Expressed in cells lacking fibronectin.

  • Immunofluorescence analysis of Hela cell. 1,AR Polyclonal Antibody(red) was diluted at 1:200(4° overnight). GFAP Monoclonal Antibody(5C8)(green) was diluted at 1:200(4° overnight). 2, Goat Anti Rabbit Alexa Fluor 594 Catalog:RS3611 was diluted at 1:1000(room temperature, 50min). Goat Anti Mouse Alexa Fluor 488 Catalog:RS3208 was diluted at 1:1000(room temperature, 50min).

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Catalog Number

  • Amount:100ul
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