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CDX2 Monoclonal Antibody(14H6)
Datasheet   

  • Catalog Number:

    E20-53057

  • Amount:

    100ul

  • Applications:

    WB;IF/ICC;IHC-p

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

  • Immunogen:

    Synthetic Peptide of CDX2

  • Source:

    Monoclonal, Mouse

  • Liu, Huiming, et al. "The role of CDX2 in renal tubular lesions during diabetic kidney disease." Aging (Albany NY) 13.5 (2021): 6782.

  • Gene Name:

    CDX2

  • Dilution:

    WB: 1:1000 IHC: 1:200 IF 1:200

  • Background:

    This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012],

  • Protein Name:

    Homeobox protein CDX-2

  • Human Gene Id:

    1045

  • Human Swiss Prot No:

    Q99626

  • Mouse Gene Id:

    12591

  • Mouse Swiss Prot No:

    P43241

  • Specificity:

    The antibody detects endogenous CDX2 proteins.

  • Formulation:

    PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CDX2; CDX3; Homeobox protein CDX-2; CDX-3; Caudal-type homeobox protein 2

  • Observed Band(KD):

    42

  • Function:

    function:Involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.,PTM:Phosphorylation of Ser-60 mediates the transactivation capacity.,similarity:Belongs to the Caudal homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,

  • Subcellular Location:

    Nucleus .

  • Expression:

    Detected in small intestine, colon and pancreas.

  • Liu, Huiming, et al. "The role of CDX2 in renal tubular lesions during diabetic kidney disease." Aging (Albany NY) 13.5 (2021): 6782.

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Catalog Number

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