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Tubulin α (Acetyl Lys112) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-40045

  • Amount:

    100ul

  • Molecular Weight:

    50136/50152/49895Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    Synthesized acetyl-peptide derived from human Tubulin α around the acetylation site of K112.

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of HepG2 cells using Acetyl-Tubulin α (K112) Polyclonal Antibody. Secondary antibody was diluted at 1:20000

  • Gene Name:

    TUBA1A/TUBA1B/TUBA1C

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

  • Background:

    Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.

  • Protein Name:

    Tubulin alpha-1A chain/Tubulin alpha-1B chain/Tubulin alpha-1C chain

  • Human Gene Id:

    7846/10376/84790

  • Human Swiss Prot No:

    Q71U36/P68363/Q9BQE3

  • Mouse Gene Id:

    22142/22143/22146

  • Rat Gene Id:

    64158/500929/100909441

  • Rat Swiss Prot No:

    P68370/Q6P9V9/Q6AYZ1

  • Specificity:

    Acetyl-Tubulin α (K112) Polyclonal Antibody detects endogenous levels of Tubulin α protein only when acetylated at K112.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    TUBA1A; TUBA3; Tubulin alpha-1A chain; Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain; TUBA1B; Tubulin alpha-1B chain; Alpha-tubulin ubiquitousTubulin K-alpha-1; Tubulin alpha-ubiquitous chain; TUBA1C; TUBA6; Tubulin alpha-1C chain; Alpha-tubulin 6; Tubulin alpha-6 chain

  • Observed Band(KD):

    50

  • Function:

    disease:Defects in TUBA1A are the cause of lissencephaly type 3 (LIS3) [MIM:611603]. LIS is characterized by a smooth brain surface due to the absence (agyria) or reduction (pachygyria) of surface convolutions. It is often associated with psychomotor retardation and seizures. LIS3 features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem.,function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,PTM:Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), resp

  • Subcellular Location:

    Cytoplasm, cytoskeleton.

  • Expression:

    Expressed at a high level in fetal brain.

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