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Ku-70 (Acetyl Lys331) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-40043

  • Amount:

    100ul

  • Molecular Weight:

    69843Da

  • Applications:

    WB;IHC-p

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized Acetyl-peptide derived from human Ku70 around the Acetylation site of Lys331. AA range:291-340

  • Source:

    Polyclonal, Rabbit,IgG

  • Western blot analysis of lysate from 4T1 cells, using Ku70 (Acetyl-Lys331) Antibody.

  • Gene Name:

    XRCC6

  • Dilution:

    WB 1:500-2000;IHC-p 1:50-300

  • Background:

    The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008],

  • Protein Name:

    X-ray repair cross-complementing protein 6

  • Human Gene Id:

    2547

  • Human Swiss Prot No:

    P12956

  • Mouse Gene Id:

    14375

  • Mouse Swiss Prot No:

    P23475

  • Specificity:

    Acetyl-Ku-70 (K331) Polyclonal Antibody detects endogenous levels of Ku-70 protein only when acetylated at K331.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit;CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6

  • Observed Band(KD):

    70

  • Function:

    developmental stage:Expression does not increase during promyelocyte differentiation.,disease:Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to p70 and p86. Existence of a major autoantigenic epitope or epitopes on the C-terminal 190 amino acids of p70 containing the leucine repeat. The majority of autoantibodies to p70 in most sera from patients with SLE seem to be reactive with this region.,function:Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The Ku p70/p86

  • Subcellular Location:

    Nucleus . Chromosome .

  • Expression:

    Brain,Cervix carcinoma,Epithelium,Heart,Hepatocyte,Kidney,Liver,Lun

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Catalog Number

  • Amount:100ul
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Ku-70 (Acetyl Lys331) Polyclonal Antibody | EnoGene Biotech Co. Ltd