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Cell Signal Transduction Research Antibodies
Acetyl Lys proteins Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized acetyl-peptide derived from human acetylation Lys proteins.
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Product Information
SpecificityAcetyl-Lys proteins Polyclonal Antibody detects endogenous levels of acetylated Lys proteins.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Observed Band(KD)20,40,80,175
BackgroundAcetylation of lysine, like phosphorylation of serine, threonine or tyrosine, is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Signaling resulting in acetylation/deacetylation of histones, transcription factors, and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity, cell growth, differentiation, and apoptosis. Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism, longevity, actin polymerization, and nuclear transport. The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases, and HDACs have become promising targets for anti-cancer drugs currently in development.
Conjugated Antibody
This product is also available conjugated. Format: E20-40020-Conjugate. Price: $485 / Size: 100μl.
E20-40020-FITC$485 / 100μlE20-40020-Biotin$485 / 100μlE20-40020-HRP$485 / 100μlE20-40020-AP$485 / 100μlE20-40020-AF350$485 / 100μlE20-40020-AF405M$485 / 100μlE20-40020-AF488$485 / 100μlE20-40020-AF514$485 / 100μlE20-40020-AF532$485 / 100μlE20-40020-AF555$485 / 100μlE20-40020-AF568$485 / 100μlE20-40020-AF405S$485 / 100μlE20-40020-AF405L$485 / 100μlE20-40020-AF546$485 / 100μlE20-40020-AF594$485 / 100μlE20-40020-AF610$485 / 100μlE20-40020-AF635$485 / 100μlE20-40020-AF647$485 / 100μlE20-40020-AF680$485 / 100μlE20-40020-AF700$485 / 100μlE20-40020-AF750$485 / 100μlE20-40020-AF790$485 / 100μlE20-40020-APC$485 / 100μlE20-40020-PE$485 / 100μlE20-40020-Cy3$485 / 100μlE20-40020-Cy5$485 / 100μlE20-40020-Cy5.5$485 / 100μlE20-40020-Cy7$485 / 100μlE20-40020-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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