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Cell Signal Transduction Research Antibodies
E20-40001
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight123968Da
Protein NamePlatelet-derived growth factor receptor beta
Human Gene Id5159
Human Swiss Prot NoP09619
Mouse Swiss Prot NoP05622
SpecificityPDGFR-β Polyclonal Antibody detects endogenous levels of PDGFR-β protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri
Observed Band(KD)124
Functioncatalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving PDGFRB is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5;12) with ETV6 on chromosome 12 creating an PDGFRB-ETV6 fusion protein.,disease:A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with EVT6/TEL. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).,disease:A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with TRIP11. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.,disease:A chromosomal aberration involving PDGFRB may be a cause
Subcellular LocationCell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
ExpressionBrain,Spleen,
Mouse Gene Id18596
Rat Gene Id24629
Rat Swiss Prot NoQ05030
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human PDGF Receptor beta. AA range:718-767
Gene NamePDGFRB
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Backgroundplatelet derived growth factor receptor beta(PDGFRB) Homo sapiens This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008],
transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells. Cell Death Dis
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PDGF Receptor beta Antibody. picture on the right is blocked with the synthesized peptide.
Conjugated Antibody
This product is also available conjugated. Format: E20-40001-Conjugate. Price: $485 / Size: 100μl.
E20-40001-FITC$485 / 100μlE20-40001-Biotin$485 / 100μlE20-40001-HRP$485 / 100μlE20-40001-AP$485 / 100μlE20-40001-AF350$485 / 100μlE20-40001-AF405M$485 / 100μlE20-40001-AF488$485 / 100μlE20-40001-AF514$485 / 100μlE20-40001-AF532$485 / 100μlE20-40001-AF555$485 / 100μlE20-40001-AF568$485 / 100μlE20-40001-AF405S$485 / 100μlE20-40001-AF405L$485 / 100μlE20-40001-AF546$485 / 100μlE20-40001-AF594$485 / 100μlE20-40001-AF610$485 / 100μlE20-40001-AF635$485 / 100μlE20-40001-AF647$485 / 100μlE20-40001-AF680$485 / 100μlE20-40001-AF700$485 / 100μlE20-40001-AF750$485 / 100μlE20-40001-AF790$485 / 100μlE20-40001-APC$485 / 100μlE20-40001-PE$485 / 100μlE20-40001-Cy3$485 / 100μlE20-40001-Cy5$485 / 100μlE20-40001-Cy5.5$485 / 100μlE20-40001-Cy7$485 / 100μlE20-40001-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
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- Tag antibodies
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- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
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- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
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