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Cleaved-Thrombin R (S42) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-10104

  • Amount:

    100ul

  • Molecular Weight:

    47441(Da) Observed Band(KD)46

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PAR1. AA range:23-72

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of Jurkat cells using Cleaved-Thrombin R (S42) Polyclonal Antibody

  • Gene Name:

    F2R

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

  • Protein Name:

    Proteinase-activated receptor 1

  • Human Gene Id:

    2149

  • Human Swiss Prot No:

    P25116

  • Mouse Swiss Prot No:

    P30558

  • Specificity:

    Cleaved-Thrombin R (S42) Polyclonal Antibody detects endogenous levels of fragment of activated Thrombin R protein resulting from cleavage adjacent to S42.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    F2R; CF2R; PAR1; TR; Proteinase-activated receptor 1; PAR-1; Coagulation factor II receptor; Thrombin receptor

  • Background:

    coagulation factor II thrombin receptor(F2R) Homo sapiens Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],

  • Function:

    function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,

  • Subcellular Location:

    extracellular region,cell,early endosome,late endosome,Golgi apparatus,plasma membrane,integral component of plasma membrane,caveola,cell surface,integral component of membrane,platelet dense tubular network,neur

  • Expression:

    Eye

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Catalog Number

  • Amount:100ul
  • Price:225$

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