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Cleaved-Spectrin α II (D1185) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-10074

  • Amount:

    100ul

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human SPTA2. AA range:1136-1185

  • Source:

    Polyclonal, Rabbit,IgG

  • Chen, W., Wang, W., Sun, X. et al. NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90. Cell Death Dis 11, 534 (2020). 

  • Gene Name:

    SPTAN1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Background:

    Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010],

  • Protein Name:

    Spectrin alpha chain non-erythrocytic 1

  • Human Gene Id:

    6709

  • Human Swiss Prot No:

    Q13813

  • Mouse Swiss Prot No:

    P16546

  • Specificity:

    Cleaved-Spectrin α II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin α II protein resulting from cleavage adjacent to D1185.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    SPTAN1; NEAS; SPTA2; Spectrin alpha chain; non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunitObserved Band:137KD

  • Function:

    function:Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.,PTM:Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.,similarity:Belongs to the spectrin family.,similarity:Contains 1 SH3 domain.,similarity:Contains 23 spectrin repeats.,similarity:Contains 3 EF-hand domains.,subunit:Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with isoform 1 of ACP1. Interacts with CALM.,

  • Subcellular Location:

    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. .

  • Expression:

    Aorta,Brain,Epithelium,Fetal brain,Fetal brain cortex,Fetal liver,LNudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90. Cell Death & Disease Cell Death Dis. 2020 Jul;11(7):1-15 WB Human A549 cell

  • Western Blot analysis of various cells using Cleaved-Spectrin α II (D1185) Polyclonal Antibody diluted at 1:500

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Catalog Number

  • Amount:100ul
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