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Cleaved-MMP-10 (F99) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-10059

  • Amount:

    100ul

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MMP10. AA range:80-129

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Cleaved-MMP-10 (F99) Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    MMP10

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

  • Background:

    This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016],

  • Protein Name:

    Stromelysin-2

  • Human Gene Id:

    4319

  • Human Swiss Prot No:

    P09238

  • Mouse Swiss Prot No:

    O55123

  • Specificity:

    Cleaved-MMP-10 (F99) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-10 protein resulting from cleavage adjacent to F99.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MMP10; STMY2; Stromelysin-2; SL-2; Matrix metalloproteinase-10; MMP-10; Transin-2Observed Band:43KD

  • Function:

    catalytic activity:Similar to stromelysin 1, but action on collagen types III, IV and V is weak.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Calcium.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,

  • Subcellular Location:

    Secreted, extracellular space, extracellular matrix .

  • Expression:

    Coronary artery,Ovary,

  • Western Blot analysis of HepG2 cells using Cleaved-MMP-10 (F99) Polyclonal Antibody diluted at 1:1000

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Catalog Number

  • Amount:100ul
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Cleaved-MMP-10 (F99) Polyclonal Antibody | EnoGene Biotech Co. Ltd