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Cleaved-Cathepsin Z (L62) Polyclonal Antibody
Datasheet
Catalog Number:
E20-10046Amount:
100ulApplications:
WB;ELISAReactivity:
Human;Mouse;Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human CATZ. AA range:43-92Source:
Polyclonal, Rabbit,IgG
- Western Blot analysis of various cells using Cleaved-Cathepsin Z (L62) Polyclonal Antibody
Gene Name:
CTSZDilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.Background:
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008],Protein Name:
Cathepsin ZHuman Gene Id:
1522Human Swiss Prot No:
Q9UBR2Mouse Swiss Prot No:
Q9WUU7Specificity:
Cleaved-Cathepsin Z (L62) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin Z protein resulting from cleavage adjacent to L62.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
CTSZ; Cathepsin Z; Cathepsin P; Cathepsin XObserved Band:27KDFunction:
catalytic activity:Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.,function:Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.,similarity:Belongs to the peptidase C1 family.,tissue specificity:Widely expressed.,Subcellular Location:
Lysosome.Expression:
Widely expressed.
- Western blot analysis of lysates from COS7 cells, treated with etoposide 25uM 1h, using CATZ (Cleaved-Leu62) Antibody. The lane on the right is blocked with the synthesized peptide.
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