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Cleaved-Cathepsin A 32k (R326) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-10034

  • Amount:

    100ul

  • Molecular Weight:

    54466Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PPGB. AA range:277-326

  • Source:

    Polyclonal, Rabbit,IgG

  • Western blot analysis of lysates from 293 and Jurkat cells, treated with etoposide 25uM 1h, using PPGB (32k,Cleaved-Arg326) Antibody. The lane on the right is blocked with the synthesized peptide.
    .

  • Gene Name:

    CTSA

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Background:

    This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015],

  • Protein Name:

    Lysosomal protective protein

  • Human Gene Id:

    5476

  • Human Swiss Prot No:

    P10619

  • Mouse Gene Id:

    19025

  • Mouse Swiss Prot No:

    P16675

  • Specificity:

    Cleaved-Cathepsin A 32k (R326) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin A 32k protein resulting from cleavage adjacent to R326.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CTSA; PPGB; Lysosomal protective protein; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; Protective protein cathepsin A; PPCA; Protective protein for beta-galactosidase

  • Observed Band(KD):

    33

  • Function:

    catalytic activity:Release of a C-terminal amino acid with broad specificity.,disease:Defects in CTSA are the cause of galactosialidosis [MIM:256540]. It is an autosomal recessive disease.,function:Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.,similarity:Belongs to the peptidase S10 family.,subunit:Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.,

  • Subcellular Location:

    Lysosome.

  • Expression:

    Brain,Liver,Placenta,Platelet,Skin,Uterus,

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Catalog Number

  • Amount:100ul
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Cleaved-Cathepsin A 32k (R326) Polyclonal Antibody | EnoGene Biotech Co. Ltd