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Lapatinib (Tykerb)
$120/ 100mg
QuantityTotal: $120
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Product Information
Kinase Inhibitor Name Lapatinib Ditosylate (Tykerb)
M.W.925.46
FormulaC29H26ClFN4O4S.2C7H8O3S
SolubilityDMSO ≥185mg/mL Water <1mg/mL Ethanol <1mg/mL
Purity99%
CAS No.388082-77-7
Biological ActivityLapatinib Ditosylate (Tykerb) was found to have 50% inhibitory concentration (IC50) values against purified EGFR and HER2 of 10.2 and 9.8 nM, respectively. And IC50 >10000nM against c-Raf-1,MEK,ERK,CDK1CDK2,p38 and VEGFR-2.
The IC50s for inhibition of cell growth by 72h treatment with GW2016 are 0.16μM for A431,0.12 μM for HN5,0.10 μM for BT474,0.09 μM for N87.
Lapatinib undergoes first-pass metabolism catalyzed by CYP3A4/5 and does not appear to be a substrate for P-glycoprotein. [2]
The IC50s for inhibition of cell growth by 72h treatment with GW2016 are 0.16μM for A431,0.12 μM for HN5,0.10 μM for BT474,0.09 μM for N87.
Lapatinib undergoes first-pass metabolism catalyzed by CYP3A4/5 and does not appear to be a substrate for P-glycoprotein. [2]
Storage/Stabilityat -20℃ 2 years
ReferencesThe pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Price120$
Research AreaStem Cells Cancer Cardiovascular Cell Biology Epigenetics & Nuclear Signaling Developmental Biologys Immunology Drug Discovery Products Metabolism Neuroscience Signal Transduction
Ditosylate (Tykerb) was found to have 50% inhibitory concentration (IC50) values EGFR and HER2 of 10.2 and 9.8 nM, respectively. And IC50 >10000nM c-Raf-1,MEK,ERK,CDK1CDK2,p38 and VEGFR-2. IC50s for inhibition of cell growth by 72h treatment with GW2016 are 0.16μM for A431,0.12 μM for BT474,0.09 μM for N87. undergoes first-pass metabolism catalyzed by CYP3A4/5 and does not appear to
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