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SFRP3 Antibody
Human;Mouse
WB;IHC;IF;ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NameFRZB FIZ FRE FRP FRZB1 SFRP3
Product Information
Protein NameSecreted frizzled-related protein 3 (sFRP-3) (Frezzled) (Fritz) (Frizzled-related protein 1) (FrzB-1)
Human Gene Id2487
Human Swiss Prot NoQ92765
Mouse Swiss Prot NoP97401
SpecificitySFRP3 Polyclonal Antibody detects endogenous levels of protein.
FormulationLiquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)35kD
Functiondisease:Defects in FRZB are associated with female-specific osteoarthritis (OA) susceptibility [MIM:165720]. It is the most prevalent form of arthritis and a common cause of disability.,domain:The FZ domain is involved in binding with Wnt ligands.,function:Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.,similarity:Belongs to the secreted frizzled-related protein (sFRP) family.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 NTR domain.
Subcellular LocationSecreted .
ExpressionExpressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly expressed in lung and liver.
ImmunogenSynthesized peptide derived from human protein . at AA range: 150-230
DilutionWB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000. IF 1:50-200
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThe protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
Western blot analysis of lysates from antibody K562 cells, primary antibody was diluted at 1:1000, 4°over night.
Immunohistochemical analysis of paraffin-embedded human Antibody was diluted at 1:200(4 ℃ overnight). 2, was used for antigen retrieval. 3,Secondary was diluted at 1:200(room temperature, 30min).
Conjugated Antibody
This product is also available conjugated. Format: E19-9879-Conjugate. Price: $485 / Size: 100μl.
E19-9879-FITC$485 / 100μlE19-9879-Biotin$485 / 100μlE19-9879-HRP$485 / 100μlE19-9879-AP$485 / 100μlE19-9879-AF350$485 / 100μlE19-9879-AF405M$485 / 100μlE19-9879-AF488$485 / 100μlE19-9879-AF514$485 / 100μlE19-9879-AF532$485 / 100μlE19-9879-AF555$485 / 100μlE19-9879-AF568$485 / 100μlE19-9879-AF405S$485 / 100μlE19-9879-AF405L$485 / 100μlE19-9879-AF546$485 / 100μlE19-9879-AF594$485 / 100μlE19-9879-AF610$485 / 100μlE19-9879-AF635$485 / 100μlE19-9879-AF647$485 / 100μlE19-9879-AF680$485 / 100μlE19-9879-AF700$485 / 100μlE19-9879-AF750$485 / 100μlE19-9879-AF790$485 / 100μlE19-9879-APC$485 / 100μlE19-9879-PE$485 / 100μlE19-9879-Cy3$485 / 100μlE19-9879-Cy5$485 / 100μlE19-9879-Cy5.5$485 / 100μlE19-9879-Cy7$485 / 100μlE19-9879-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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