Catalog Number:
E047804Amount:
100μg/100μlPrice:
255$Species:
RabbitAntibody type:
PolyclonalPurification:
Antigen affinity purificationApplications:
IHCRecommended Dilutions:
IHC dilution:1: 20-100Reactivity:
Hu, Ms, RtSpecificity/Sensitivity:
The antibody detects endogenous levels of total ITGB4 protein.Gene Name:
ITGB4Altername:
CD104; GP150Immunogen:
Synthetic peptide of human ITGB4Concentration:
0.7Form of Antibody:
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.Storage/Stability:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.Background:
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.Swiss-Prot No.:
P16144Gene ID:
3691;