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GK1/3 Polyclonal Antibody
：Human;Rat;Mouse;
： WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NameGK/GK3P
Product Information
Protein NamePutative glycerol kinase 3
Human Gene Id2713
Human Swiss Prot NoP32189/Q14409
SpecificityGK1/3 Polyclonal Antibody detects endogenous levels of GK1/3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGK; Glycerol kinase; GK; Glycerokinase; ATP:glycerol 3-phosphotransferase; GK3P; GKP3; GKTB; Putative glycerol kinase 3; GK 3; Glycerokinase 3; ATP:glycerol 3-phosphotransferase 3; Glycerol kinase; testis specific 1
Molecular Weight60570DaObserved Band:61KD
Functioncatalytic activity:ATP + glycerol = ADP + sn-glycerol 3-phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in GK are the cause of GK deficiency (GKD) [MIM:307030]. This disease can be either symptomatic with episodic metabolic and CNS decompensation or asymptomatic with hyperglycerolemia and hyperglyceroluria only.,function:Key enzyme in the regulation of glycerol uptake and metabolism.,pathway:Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.,similarity:Belongs to the FGGY kinase family.,subcellular location:In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.,tissue specificity:Highly expressed in the liver, kidney and testis
Subcellular LocationMitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.
ExpressionHighly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver.
ImmunogenThe antiserum was produced against synthesized peptide derived from human GK3. AA range:21-70
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThe protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-71911-Conjugate. Price: $485 / Size: 100μl.
：E20-71911-FITC$485 / 100μl：E20-71911-Biotin$485 / 100μl：E20-71911-HRP$485 / 100μl：E20-71911-AP$485 / 100μl：E20-71911-AF350$485 / 100μl：E20-71911-AF405M$485 / 100μl：E20-71911-AF488$485 / 100μl：E20-71911-AF514$485 / 100μl：E20-71911-AF532$485 / 100μl：E20-71911-AF555$485 / 100μl：E20-71911-AF568$485 / 100μl：E20-71911-AF405S$485 / 100μl：E20-71911-AF405L$485 / 100μl：E20-71911-AF546$485 / 100μl：E20-71911-AF594$485 / 100μl：E20-71911-AF610$485 / 100μl：E20-71911-AF635$485 / 100μl：E20-71911-AF647$485 / 100μl：E20-71911-AF680$485 / 100μl：E20-71911-AF700$485 / 100μl：E20-71911-AF750$485 / 100μl：E20-71911-AF790$485 / 100μl：E20-71911-APC$485 / 100μl：E20-71911-PE$485 / 100μl：E20-71911-Cy3$485 / 100μl：E20-71911-Cy5$485 / 100μl：E20-71911-Cy5.5$485 / 100μl：E20-71911-Cy7$485 / 100μl：E20-71911-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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