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E20-71909
：Human;Mouse;Rat
： WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
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Gene NameGIT2
Product Information
Protein NameARF GTPase-activating protein GIT2
Human Gene Id9815
Human Swiss Prot NoQ14161
Mouse Gene Id26431
Mouse Swiss Prot NoQ9JLQ2
SpecificityGIT2 Polyclonal Antibody detects endogenous levels of GIT2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGIT2; KIAA0148; ARF GTPase-activating protein GIT2; ARF GAP GIT2; Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2
Molecular Weight84543DaObserved Band:84KD
Functionalternative products:Additional isoforms seem to exist,function:GTPase-activating protein for the ADP ribosylation factor family.,similarity:Contains 1 Arf-GAP domain.,similarity:Contains 3 ANK repeats.,subunit:Interacts with TGFB1I1 (By similarity). Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors.,
Subcellular Locationnucleoplasm,focal adhesion,
ExpressionB-cell,Bone marrow,Cerebellum,Dermoid cancer,Epithelium,Skin,T-cell,
ImmunogenThe antiserum was produced against synthesized peptide derived from human GIT2. AA range:361-410
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThis gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G
analysis of HeLa cells, using GK Antibody. The right is blocked with the synthesized peptide.
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