Product Information
Protein NameGastric inhibitory polypeptide receptor
Human Gene Id2696
Human Swiss Prot NoP48546
Mouse Swiss Prot NoQ0P543
SpecificityGIPR Polyclonal Antibody detects endogenous levels of GIPR protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGIPR; Gastric inhibitory polypeptide receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor
Molecular Weight53157DaObserved Band:53KD
Functionfunction:This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 2 family.,
Subcellular LocationCell membrane; Multi-pass membrane protein.
ExpressionColon,G-protein coupled receptors,Pancreas,
BackgroundThis gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011],