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GIMAP5 Polyclonal Antibody
：Human;Rat;Mouse;, Gene Name:GIMAP5
： WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Protein NameGTPase IMAP family member 5
Human Gene Id55340
Human Swiss Prot NoQ96F15
Mouse Swiss Prot NoQ8BWF2
SpecificityGIMAP5 Polyclonal Antibody detects endogenous levels of GIMAP5 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGIMAP5; IAN4L1; IAN5; IMAP3; GTPase IMAP family member 5; Immunity-associated nucleotide 4-like 1 protein; Immunity-associated nucleotide 5 protein; IAN-5; hIAN5; Immunity-associated protein 3
Molecular Weight34846DaObserved Band:35KD
Functionfunction:Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence.,similarity:Belongs to the IAN GTP-binding protein family.,tissue specificity:Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T-cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms.,
Subcellular LocationLysosome membrane ; Single-pass type IV membrane protein . Endosome, multivesicular body membrane ; Single-pass type IV membrane protein . Endosome membrane ; Single-pass type IV membrane protein . The mitochondrial localization originally reported was observed with C-terminally tagged protein and was not confirmed in later publications. .
ExpressionWidely expressed with high levels in lymph node and spleen (PubMed:14724691). High expression found in T lymphocytes, including CD4 and CD8-positive T-cells, and monocytes (PubMed:14724691, PubMed:29382851). Very low expression levels in B-lymphocytes (PubMed:14724691).
ImmunogenThe antiserum was produced against synthesized peptide derived from human GIMAP5. AA range:231-280
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThis gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-71905-Conjugate. Price: $485 / Size: 100μl.
：E20-71905-FITC$485 / 100μl：E20-71905-Biotin$485 / 100μl：E20-71905-HRP$485 / 100μl：E20-71905-AP$485 / 100μl：E20-71905-AF350$485 / 100μl：E20-71905-AF405M$485 / 100μl：E20-71905-AF488$485 / 100μl：E20-71905-AF514$485 / 100μl：E20-71905-AF532$485 / 100μl：E20-71905-AF555$485 / 100μl：E20-71905-AF568$485 / 100μl：E20-71905-AF405S$485 / 100μl：E20-71905-AF405L$485 / 100μl：E20-71905-AF546$485 / 100μl：E20-71905-AF594$485 / 100μl：E20-71905-AF610$485 / 100μl：E20-71905-AF635$485 / 100μl：E20-71905-AF647$485 / 100μl：E20-71905-AF680$485 / 100μl：E20-71905-AF700$485 / 100μl：E20-71905-AF750$485 / 100μl：E20-71905-AF790$485 / 100μl：E20-71905-APC$485 / 100μl：E20-71905-PE$485 / 100μl：E20-71905-Cy3$485 / 100μl：E20-71905-Cy5$485 / 100μl：E20-71905-Cy5.5$485 / 100μl：E20-71905-Cy7$485 / 100μl：E20-71905-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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