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Ghrelin Polyclonal Antibody
：Human;Mouse;Rat
：WB;IHC-p;IF/ICC;ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NameGHRL
Product Information
Protein NameAppetite-regulating hormone
Human Gene Id51738
Human Swiss Prot NoQ9UBU3
Mouse Gene Id58991
Mouse Swiss Prot NoQ9EQX0
Rat Gene Id59301
Rat Swiss Prot NoQ9QYH7
SpecificityGhrelin Polyclonal Antibody detects endogenous levels of Ghrelin protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGHRL; MTLRP; Appetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Protein M46
Molecular Weight12911DaObserved Band:13KD
Functionfunction:Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.,function:Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.,mass spectrometry:Ghrelin-27-C10, O-decanoylated form PubMed:12414809,mass spectrometry:Ghrelin-27-C8, O-octanoylated form PubMed:12414809,mass spectrometry:Ghrelin-28-C10, O-decanoylated form PubMed:12414809,mass spectrometry:Ghrelin-28-C10:1, O-decenoylated form PubMed:12414809,mass spectrometry:Ghrelin-28-C8, O-octanoylated form PubMed:12414809,online information:Ghrelin entry,online information:Gut feelings - Issue 66 of January 2006,PTM:Amida
Subcellular LocationSecreted.
ExpressionHighest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy
ImmunogenThe antiserum was produced against synthesized peptide derived from human Ghrelin. AA range:47-96
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThis gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function
Conjugated Antibody
This product is also available conjugated. Format: ：E20-71900-Conjugate. Price: $485 / Size: 100μl.
：E20-71900-FITC$485 / 100μl：E20-71900-Biotin$485 / 100μl：E20-71900-HRP$485 / 100μl：E20-71900-AP$485 / 100μl：E20-71900-AF350$485 / 100μl：E20-71900-AF405M$485 / 100μl：E20-71900-AF488$485 / 100μl：E20-71900-AF514$485 / 100μl：E20-71900-AF532$485 / 100μl：E20-71900-AF555$485 / 100μl：E20-71900-AF568$485 / 100μl：E20-71900-AF405S$485 / 100μl：E20-71900-AF405L$485 / 100μl：E20-71900-AF546$485 / 100μl：E20-71900-AF594$485 / 100μl：E20-71900-AF610$485 / 100μl：E20-71900-AF635$485 / 100μl：E20-71900-AF647$485 / 100μl：E20-71900-AF680$485 / 100μl：E20-71900-AF700$485 / 100μl：E20-71900-AF750$485 / 100μl：E20-71900-AF790$485 / 100μl：E20-71900-APC$485 / 100μl：E20-71900-PE$485 / 100μl：E20-71900-Cy3$485 / 100μl：E20-71900-Cy5$485 / 100μl：E20-71900-Cy5.5$485 / 100μl：E20-71900-Cy7$485 / 100μl：E20-71900-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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