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GCS-β-1 Polyclonal Antibody
：Human;Mouse;Rat
：WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NameGUCY1B3
Product Information
Protein NameGuanylate cyclase soluble subunit beta-1
Human Gene Id2983
Human Swiss Prot NoQ02153
Mouse Gene Id54195
Mouse Swiss Prot NoO54865
Rat Gene Id25202
Rat Swiss Prot NoP20595
SpecificityGCS-β-1 Polyclonal Antibody detects endogenous levels of GCS-β-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGUCY1B3; GUC1B3; GUCSB3; GUCY1B1; Guanylate cyclase soluble subunit beta-1; GCS-beta-1; Guanylate cyclase soluble subunit beta-3; GCS-beta-3; Soluble guanylate cyclase small subunit
Molecular Weight70514DaObserved Band:70KD
Functioncatalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,cofactor:Binds 1 or 2 heme groups per heterodimer.,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions.,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,subunit:Heterodimer of an alpha and a beta chain.,
Subcellular LocationCytoplasm .
ExpressionDetected in brain cortex and cerebellum (at protein level).
ImmunogenThe antiserum was produced against synthesized peptide derived from human Guanylate Cyclase beta. AA range:10-59
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThis gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-71886-Conjugate. Price: $485 / Size: 100μl.
：E20-71886-FITC$485 / 100μl：E20-71886-Biotin$485 / 100μl：E20-71886-HRP$485 / 100μl：E20-71886-AP$485 / 100μl：E20-71886-AF350$485 / 100μl：E20-71886-AF405M$485 / 100μl：E20-71886-AF488$485 / 100μl：E20-71886-AF514$485 / 100μl：E20-71886-AF532$485 / 100μl：E20-71886-AF555$485 / 100μl：E20-71886-AF568$485 / 100μl：E20-71886-AF405S$485 / 100μl：E20-71886-AF405L$485 / 100μl：E20-71886-AF546$485 / 100μl：E20-71886-AF594$485 / 100μl：E20-71886-AF610$485 / 100μl：E20-71886-AF635$485 / 100μl：E20-71886-AF647$485 / 100μl：E20-71886-AF680$485 / 100μl：E20-71886-AF700$485 / 100μl：E20-71886-AF750$485 / 100μl：E20-71886-AF790$485 / 100μl：E20-71886-APC$485 / 100μl：E20-71886-PE$485 / 100μl：E20-71886-Cy3$485 / 100μl：E20-71886-Cy5$485 / 100μl：E20-71886-Cy5.5$485 / 100μl：E20-71886-Cy7$485 / 100μl：E20-71886-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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