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GCS-α-1 Polyclonal Antibody
：Human;Mouse;Rat
：WB;CoIP;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NameGUCY1A3
Product Information
Protein NameGuanylate cyclase soluble subunit alpha-3
Human Gene Id2982
Human Swiss Prot NoQ02108
Mouse Gene Id60596
Mouse Swiss Prot NoQ9ERL9
Rat Swiss Prot NoP19686
SpecificityGCS-α-1 Polyclonal Antibody detects endogenous levels of GCS-α-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGUCY1A3; GUC1A3; GUCSA3; GUCY1A1; Guanylate cyclase soluble subunit alpha-3; GCS-alpha-3; GCS-alpha-1; Soluble guanylate cyclase large subunit
Molecular Weight77452DaObserved Band:77KD
Functioncatalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions.,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,subunit:Heterodimer of an alpha and a beta chain.,
Subcellular LocationCytoplasm .
ExpressionDetected in brain cortex and lung (at protein level).
ImmunogenThe antiserum was produced against synthesized peptide derived from human GCS-alpha-1. AA range:374-423
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundSoluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-71885-Conjugate. Price: $485 / Size: 100μl.
：E20-71885-FITC$485 / 100μl：E20-71885-Biotin$485 / 100μl：E20-71885-HRP$485 / 100μl：E20-71885-AP$485 / 100μl：E20-71885-AF350$485 / 100μl：E20-71885-AF405M$485 / 100μl：E20-71885-AF488$485 / 100μl：E20-71885-AF514$485 / 100μl：E20-71885-AF532$485 / 100μl：E20-71885-AF555$485 / 100μl：E20-71885-AF568$485 / 100μl：E20-71885-AF405S$485 / 100μl：E20-71885-AF405L$485 / 100μl：E20-71885-AF546$485 / 100μl：E20-71885-AF594$485 / 100μl：E20-71885-AF610$485 / 100μl：E20-71885-AF635$485 / 100μl：E20-71885-AF647$485 / 100μl：E20-71885-AF680$485 / 100μl：E20-71885-AF700$485 / 100μl：E20-71885-AF750$485 / 100μl：E20-71885-AF790$485 / 100μl：E20-71885-APC$485 / 100μl：E20-71885-PE$485 / 100μl：E20-71885-Cy3$485 / 100μl：E20-71885-Cy5$485 / 100μl：E20-71885-Cy5.5$485 / 100μl：E20-71885-Cy7$485 / 100μl：E20-71885-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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