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GCSm-γ Polyclonal Antibody
：Human;Mouse;Rat;Monkey
：WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NameGCLM
Product Information
Protein NameGlutamate--cysteine ligase regulatory subunit
Human Gene Id2730
Human Swiss Prot NoP48507
Mouse Gene Id14630
Mouse Swiss Prot NoO09172
Rat Gene Id29739
Rat Swiss Prot NoP48508
SpecificityGCSm-γ Polyclonal Antibody detects endogenous levels of GCSm-γ protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGCLM; GLCLR; Glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit
Molecular Weight30727DaObserved Band:31KD
Functionpathway:Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.,similarity:Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.,subunit:Heterodimer of a catalytic heavy chain and a regulatory light chain.,tissue specificity:In all tissues examined. Highest levels in skeletal muscle.,
Subcellular Locationcytosol,glutamate-cysteine ligase complex,
ExpressionIn all tissues examined. Highest levels in skeletal muscle.
ImmunogenThe antiserum was produced against synthesized peptide derived from human GCSm-gamma. AA range:42-91
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundGlutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-71884-Conjugate. Price: $485 / Size: 100μl.
：E20-71884-FITC$485 / 100μl：E20-71884-Biotin$485 / 100μl：E20-71884-HRP$485 / 100μl：E20-71884-AP$485 / 100μl：E20-71884-AF350$485 / 100μl：E20-71884-AF405M$485 / 100μl：E20-71884-AF488$485 / 100μl：E20-71884-AF514$485 / 100μl：E20-71884-AF532$485 / 100μl：E20-71884-AF555$485 / 100μl：E20-71884-AF568$485 / 100μl：E20-71884-AF405S$485 / 100μl：E20-71884-AF405L$485 / 100μl：E20-71884-AF546$485 / 100μl：E20-71884-AF594$485 / 100μl：E20-71884-AF610$485 / 100μl：E20-71884-AF635$485 / 100μl：E20-71884-AF647$485 / 100μl：E20-71884-AF680$485 / 100μl：E20-71884-AF700$485 / 100μl：E20-71884-AF750$485 / 100μl：E20-71884-AF790$485 / 100μl：E20-71884-APC$485 / 100μl：E20-71884-PE$485 / 100μl：E20-71884-Cy3$485 / 100μl：E20-71884-Cy5$485 / 100μl：E20-71884-Cy5.5$485 / 100μl：E20-71884-Cy7$485 / 100μl：E20-71884-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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