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GATA-4 Polyclonal Antibody
：Human;Rat;Mouse;
：WB;IF/ICC;ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NameGATA4
Product Information
Protein NameTranscription factor GATA-4
Human Gene Id2626
Human Swiss Prot NoP43694
Mouse Gene Id14463
Mouse Swiss Prot NoQ08369
Rat Gene Id54254
Rat Swiss Prot NoP46152
SpecificityGATA-4 Polyclonal Antibody detects endogenous levels of GATA-4 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGATA4; Transcription factor GATA-4; GATA-binding factor 4
Molecular Weight44627DaObserved Band:48KD
Functiondisease:Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.,function:Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5.,similarity:Contains 2 GATA-type zinc fingers.,subunit:Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its a
Subcellular LocationNucleus .
ExpressionHeart,Lung,
ImmunogenThe antiserum was produced against synthesized peptide derived from human GATA4. AA range:228-277
DilutionWestern Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThis gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-71863-Conjugate. Price: $485 / Size: 100μl.
：E20-71863-FITC$485 / 100μl：E20-71863-Biotin$485 / 100μl：E20-71863-HRP$485 / 100μl：E20-71863-AP$485 / 100μl：E20-71863-AF350$485 / 100μl：E20-71863-AF405M$485 / 100μl：E20-71863-AF488$485 / 100μl：E20-71863-AF514$485 / 100μl：E20-71863-AF532$485 / 100μl：E20-71863-AF555$485 / 100μl：E20-71863-AF568$485 / 100μl：E20-71863-AF405S$485 / 100μl：E20-71863-AF405L$485 / 100μl：E20-71863-AF546$485 / 100μl：E20-71863-AF594$485 / 100μl：E20-71863-AF610$485 / 100μl：E20-71863-AF635$485 / 100μl：E20-71863-AF647$485 / 100μl：E20-71863-AF680$485 / 100μl：E20-71863-AF700$485 / 100μl：E20-71863-AF750$485 / 100μl：E20-71863-AF790$485 / 100μl：E20-71863-APC$485 / 100μl：E20-71863-PE$485 / 100μl：E20-71863-Cy3$485 / 100μl：E20-71863-Cy5$485 / 100μl：E20-71863-Cy5.5$485 / 100μl：E20-71863-Cy7$485 / 100μl：E20-71863-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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