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E20-71233
：Human,Mouse,Rat
：Polyclonal, Rabbit
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Gene Name：CYP4B1
Product Information
Protein Name：Cytochrome P450 4B1
Human Gene Id：1580
Human Swiss Prot No：P13584
Specificity：CYP4B1 Polyclonal Antibody detects endogenous levels of CYP4B1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：CYP4B1; Cytochrome P450 4B1; CYPIVB1; Cytochrome P450-HP
Molecular Weight(Da)：58991
Observed Band(KD)：50
Function：catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.,induction:P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.,online information:CYP4B1 alleles,similarity:Belongs to the cytochrome P450 family.,
Subcellular Location：endoplasmic reticulum membrane,integral component of membrane,organelle membrane,
Immunogen：The antiserum was produced against synthesized peptide derived from human Cytochrome P450 4B1. AA range:141-190
Dilution：Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background：cytochrome P450 family 4 subfamily B member 1(CYP4B1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016],
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