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Bmx Polyclonal Antibody
： Human;Mouse;Rat
： WB;ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NameBMX
Product Information
Protein NameCytoplasmic tyrosine-protein kinase BMX
Human Gene Id660
Human Swiss Prot NoP51813
Mouse Gene Id12169
Mouse Swiss Prot NoP97504
SpecificityBmx Polyclonal Antibody detects endogenous levels of Bmx protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameBMX; Cytoplasmic tyrosine-protein kinase BMX; Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38
Molecular Weight78011DaObserved Band:75KD
Functioncatalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,cofactor:Binds 1 zinc ion per subunit.,domain:SH2 domain mediates interaction with RUFY1.,function:Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.,induction:Activated by IL-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with RUFY1 and RUFY2.,tissue sp
Subcellular LocationCytoplasm . Localizes to the edges of spreading cells when complexed with BCAR1.
ExpressionHighly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.
ImmunogenThe antiserum was produced against synthesized peptide derived from N-ternal human BMX. AA range:11-60
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThis gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70507-Conjugate. Price: $485 / Size: 100μl.
：E20-70507-FITC$485 / 100μl：E20-70507-Biotin$485 / 100μl：E20-70507-HRP$485 / 100μl：E20-70507-AP$485 / 100μl：E20-70507-AF350$485 / 100μl：E20-70507-AF405M$485 / 100μl：E20-70507-AF488$485 / 100μl：E20-70507-AF514$485 / 100μl：E20-70507-AF532$485 / 100μl：E20-70507-AF555$485 / 100μl：E20-70507-AF568$485 / 100μl：E20-70507-AF405S$485 / 100μl：E20-70507-AF405L$485 / 100μl：E20-70507-AF546$485 / 100μl：E20-70507-AF594$485 / 100μl：E20-70507-AF610$485 / 100μl：E20-70507-AF635$485 / 100μl：E20-70507-AF647$485 / 100μl：E20-70507-AF680$485 / 100μl：E20-70507-AF700$485 / 100μl：E20-70507-AF750$485 / 100μl：E20-70507-AF790$485 / 100μl：E20-70507-APC$485 / 100μl：E20-70507-PE$485 / 100μl：E20-70507-Cy3$485 / 100μl：E20-70507-Cy5$485 / 100μl：E20-70507-Cy5.5$485 / 100μl：E20-70507-Cy7$485 / 100μl：E20-70507-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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