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BMP-7 Polyclonal Antibody
： Human;Mouse;Rat
： WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NameBMP7
Product Information
Protein NameBone morphogenetic protein 7
Human Gene Id655
Human Swiss Prot NoP18075
Mouse Gene Id12162
Mouse Swiss Prot NoP23359
SpecificityBMP-7 Polyclonal Antibody detects endogenous levels of BMP-7 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameBMP7; OP1; Bone morphogenetic protein 7; BMP-7; Osteogenic protein 1; OP-1; Eptotermin alfa
Molecular Weight49313DaObserved Band:55KD
Functionfunction:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 7 entry,pharmaceutical:Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.,PTM:Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1.,tissue specificity:Expressed in the kidneys and bladder. Lower levels seen in the brain.,
Subcellular LocationSecreted.
ExpressionExpressed in the kidney and bladder. Lower levels seen in the brain.
ImmunogenThe antiserum was produced against synthesized peptide derived from human BMP-7. AA range:124-173
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThis gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70503-Conjugate. Price: $485 / Size: 100μl.
：E20-70503-FITC$485 / 100μl：E20-70503-Biotin$485 / 100μl：E20-70503-HRP$485 / 100μl：E20-70503-AP$485 / 100μl：E20-70503-AF350$485 / 100μl：E20-70503-AF405M$485 / 100μl：E20-70503-AF488$485 / 100μl：E20-70503-AF514$485 / 100μl：E20-70503-AF532$485 / 100μl：E20-70503-AF555$485 / 100μl：E20-70503-AF568$485 / 100μl：E20-70503-AF405S$485 / 100μl：E20-70503-AF405L$485 / 100μl：E20-70503-AF546$485 / 100μl：E20-70503-AF594$485 / 100μl：E20-70503-AF610$485 / 100μl：E20-70503-AF635$485 / 100μl：E20-70503-AF647$485 / 100μl：E20-70503-AF680$485 / 100μl：E20-70503-AF700$485 / 100μl：E20-70503-AF750$485 / 100μl：E20-70503-AF790$485 / 100μl：E20-70503-APC$485 / 100μl：E20-70503-PE$485 / 100μl：E20-70503-Cy3$485 / 100μl：E20-70503-Cy5$485 / 100μl：E20-70503-Cy5.5$485 / 100μl：E20-70503-Cy7$485 / 100μl：E20-70503-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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