Product Information
Protein NameBone morphogenetic protein 5
Human Gene Id653
Human Swiss Prot NoP22003
Mouse Gene Id12160
Mouse Swiss Prot NoP49003
SpecificityBMP-5 Polyclonal Antibody detects endogenous levels of BMP-5 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameBMP5; Bone morphogenetic protein 5; BMP-5
Molecular Weight51737DaObserved Band:52KD
Functionfunction:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 5 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in the lung and liver.,
Subcellular LocationSecreted.
ExpressionExpressed in the lung and liver.
BackgroundThis gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016],