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BM28 Polyclonal Antibody
： Human;Mouse
：WB;IHC-p;IF/ICC;ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NameMCM2
Product Information
Protein NameDNA replication licensing factor MCM2
Human Gene Id4171
Human Swiss Prot NoP49736
Mouse Gene Id17216
Mouse Swiss Prot NoP97310
SpecificityBM28 Polyclonal Antibody detects endogenous levels of BM28 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMCM2; BM28; CCNL1; CDCL1; KIAA0030; DNA replication licensing factor MCM2; Minichromosome maintenance protein 2 homolog; Nuclear protein BM28
Molecular Weight101896DaObserved Band:120KD
Functionfunction:Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.,PTM:Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,subunit:Interacts with DBF4 (By similarity). Interacts with MYST2. May interact with MCM10.,
Subcellular LocationNucleus . Chromosome . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. .
ExpressionBone marrow,Brain,Cervix carcinoma,Colon carcinoma,Epitheli
ImmunogenThe antiserum was produced against synthesized peptide derived from human MCM2. AA range:1-50
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThe protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70495-Conjugate. Price: $485 / Size: 100μl.
：E20-70495-FITC$485 / 100μl：E20-70495-Biotin$485 / 100μl：E20-70495-HRP$485 / 100μl：E20-70495-AP$485 / 100μl：E20-70495-AF350$485 / 100μl：E20-70495-AF405M$485 / 100μl：E20-70495-AF488$485 / 100μl：E20-70495-AF514$485 / 100μl：E20-70495-AF532$485 / 100μl：E20-70495-AF555$485 / 100μl：E20-70495-AF568$485 / 100μl：E20-70495-AF405S$485 / 100μl：E20-70495-AF405L$485 / 100μl：E20-70495-AF546$485 / 100μl：E20-70495-AF594$485 / 100μl：E20-70495-AF610$485 / 100μl：E20-70495-AF635$485 / 100μl：E20-70495-AF647$485 / 100μl：E20-70495-AF680$485 / 100μl：E20-70495-AF700$485 / 100μl：E20-70495-AF750$485 / 100μl：E20-70495-AF790$485 / 100μl：E20-70495-APC$485 / 100μl：E20-70495-PE$485 / 100μl：E20-70495-Cy3$485 / 100μl：E20-70495-Cy5$485 / 100μl：E20-70495-Cy5.5$485 / 100μl：E20-70495-Cy7$485 / 100μl：E20-70495-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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