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BLNK Polyclonal Antibody
： Human;Mouse
：WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene NameBLNK
Product Information
Protein NameB-cell linker protein
Human Gene Id29760
Human Swiss Prot NoQ8WV28
Mouse Gene Id17060
Mouse Swiss Prot NoQ9QUN3
SpecificityBLNK Polyclonal Antibody detects endogenous levels of BLNK protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameBLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa;
Molecular Weight50466DaObserved Band:50KD
Functiondisease:Defects in BLNK are the cause of hypoglobulinemia and absent B-cells [MIM:604515]. This is a developmental blockage at the pro- to pre-B-cell transition.,disease:In 6 of 34 childhood pre-B acute lymphoblastic leukemia (ALL) samples that were tested showed a complete loss or drastic reduction of BLNK expression.,function:Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated ac
Subcellular LocationCytoplasm . Cell membrane . BCR activation results in the translocation to membrane fraction.
ExpressionExpressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
ImmunogenThe antiserum was produced against synthesized peptide derived from human BLNK. AA range:62-111
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThis gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70494-Conjugate. Price: $485 / Size: 100μl.
：E20-70494-FITC$485 / 100μl：E20-70494-Biotin$485 / 100μl：E20-70494-HRP$485 / 100μl：E20-70494-AP$485 / 100μl：E20-70494-AF350$485 / 100μl：E20-70494-AF405M$485 / 100μl：E20-70494-AF488$485 / 100μl：E20-70494-AF514$485 / 100μl：E20-70494-AF532$485 / 100μl：E20-70494-AF555$485 / 100μl：E20-70494-AF568$485 / 100μl：E20-70494-AF405S$485 / 100μl：E20-70494-AF405L$485 / 100μl：E20-70494-AF546$485 / 100μl：E20-70494-AF594$485 / 100μl：E20-70494-AF610$485 / 100μl：E20-70494-AF635$485 / 100μl：E20-70494-AF647$485 / 100μl：E20-70494-AF680$485 / 100μl：E20-70494-AF700$485 / 100μl：E20-70494-AF750$485 / 100μl：E20-70494-AF790$485 / 100μl：E20-70494-APC$485 / 100μl：E20-70494-PE$485 / 100μl：E20-70494-Cy3$485 / 100μl：E20-70494-Cy5$485 / 100μl：E20-70494-Cy5.5$485 / 100μl：E20-70494-Cy7$485 / 100μl：E20-70494-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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