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BID Polyclonal Antibody

：E20-70488DatasheetCOAMSDS
：Human;Rat;Mouse;
：WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
Price on request
Quantity

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

Gene NameBID

Product Information

Protein NameBH3-interacting domain death agonist
Human Gene Id637
Human Swiss Prot NoP55957
Mouse Gene Id12122
Mouse Swiss Prot NoP70444
SpecificityBID Polyclonal Antibody detects endogenous levels of BID protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameBID; BH3-interacting domain death agonist; p22 BID; BID
Molecular Weight21995DaObserved Band:25KD
Functiondomain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.,function:The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.,subcellular location:A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.,subcellular location:Associated with the mitochondrial membrane.,subcellular location:Translocates to mitochondria as an integral membrane protein.,subcellular location:When uncleaved
Subcellular LocationCytoplasm . Mitochondrion membrane . Mitochondrion outer membrane . When uncleaved, it is predominantly cytoplasmic. .; [BH3-interacting domain death agonist p15]: Mitochondrion membrane . Translocates to mitochondria as an integral membrane protein. .; [BH3-interacting domain death agonist p13]: Mitochondrion membrane . Associated with the mitochondrial membrane. .; [Isoform 1]: Cytoplasm .; [Isoform 3]: Cytoplasm .; [Isoform 2]: Mitochondrion membrane . A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. .
Expression[Isoform 2]: Expressed in spleen, pancreas and placenta (at protein level). ; [Isoform 3]: Expressed in lung, pancreas and spleen (at protein level). ; [Isoform 4]: Expressed in lung and pancreas (at protein level).
ImmunogenThe antiserum was produced against synthesized peptide derived from human BID. AA range:44-93
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BackgroundThis gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008],
📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: ：E20-70488-Conjugate. Price: $485 / Size: 100μl.

：E20-70488-FITC$485 / 100μl：E20-70488-Biotin$485 / 100μl：E20-70488-HRP$485 / 100μl：E20-70488-AP$485 / 100μl：E20-70488-AF350$485 / 100μl：E20-70488-AF405M$485 / 100μl：E20-70488-AF488$485 / 100μl：E20-70488-AF514$485 / 100μl：E20-70488-AF532$485 / 100μl：E20-70488-AF555$485 / 100μl：E20-70488-AF568$485 / 100μl：E20-70488-AF405S$485 / 100μl：E20-70488-AF405L$485 / 100μl：E20-70488-AF546$485 / 100μl：E20-70488-AF594$485 / 100μl：E20-70488-AF610$485 / 100μl：E20-70488-AF635$485 / 100μl：E20-70488-AF647$485 / 100μl：E20-70488-AF680$485 / 100μl：E20-70488-AF700$485 / 100μl：E20-70488-AF750$485 / 100μl：E20-70488-AF790$485 / 100μl：E20-70488-APC$485 / 100μl：E20-70488-PE$485 / 100μl：E20-70488-Cy3$485 / 100μl：E20-70488-Cy5$485 / 100μl：E20-70488-Cy5.5$485 / 100μl：E20-70488-Cy7$485 / 100μl：E20-70488-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.

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BID Polyclonal Antibody | EnoGene Biotech Co. Ltd