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BCSC-1 Polyclonal Antibody
：Human;Rat;Mouse;
： WB;ELISA
：Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene Name：VWA5A
Product Information
Protein Name：von Willebrand factor A domain-containing protein 5A
Human Gene Id：4013
Human Swiss Prot No：O00534
Mouse Swiss Prot No：Q99KC8
Specificity：BCSC-1 Polyclonal Antibody detects endogenous levels of BCSC-1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：VWA5A; BCSC1; LOH11CR2A; von Willebrand factor A domain-containing protein 5A; Breast cancer suppressor candidate 1; BCSC-1; Loss of heterozygosity 11 chromosomal region 2 gene A protein
Molecular Weight：86489DaObserved Band：86KD
Subcellular Location：nucleus,nucleoplasm,
Expression：Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.
Immunogen：The antiserum was produced against synthesized peptide derived from human LHR2A. AA range:371-420
Dilution：Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background：VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. Existing as four alternatively spliced isoforms, the gene encoding VWA5A maps to human chromosome 11q24.2.
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70483-Conjugate. Price: $485 / Size: 100μl.
：E20-70483-FITC$485 / 100μl：E20-70483-Biotin$485 / 100μl：E20-70483-HRP$485 / 100μl：E20-70483-AP$485 / 100μl：E20-70483-AF350$485 / 100μl：E20-70483-AF405M$485 / 100μl：E20-70483-AF488$485 / 100μl：E20-70483-AF514$485 / 100μl：E20-70483-AF532$485 / 100μl：E20-70483-AF555$485 / 100μl：E20-70483-AF568$485 / 100μl：E20-70483-AF405S$485 / 100μl：E20-70483-AF405L$485 / 100μl：E20-70483-AF546$485 / 100μl：E20-70483-AF594$485 / 100μl：E20-70483-AF610$485 / 100μl：E20-70483-AF635$485 / 100μl：E20-70483-AF647$485 / 100μl：E20-70483-AF680$485 / 100μl：E20-70483-AF700$485 / 100μl：E20-70483-AF750$485 / 100μl：E20-70483-AF790$485 / 100μl：E20-70483-APC$485 / 100μl：E20-70483-PE$485 / 100μl：E20-70483-Cy3$485 / 100μl：E20-70483-Cy5$485 / 100μl：E20-70483-Cy5.5$485 / 100μl：E20-70483-Cy7$485 / 100μl：E20-70483-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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