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Bcr Polyclonal Antibody
：Human;Mouse
：WB;IHC-p;IF(paraffin section);ELISA
：Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene Name：BCR
Product Information
Protein Name：Breakpoint cluster region protein
Human Gene Id：613
Human Swiss Prot No：P11274
Mouse Gene Id：110279
Mouse Swiss Prot No：Q6PAJ1
Specificity：Bcr Polyclonal Antibody detects endogenous levels of Bcr protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：BCR; BCR1; D22S11; Breakpoint cluster region protein; Renal carcinoma antigen NY-REN-26
Molecular Weight：142819DaObserved Band：145KD
Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).,domain:The DH domain is involved in interaction with CCPG1.,domain:The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.,function:GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.,PTM:Autophosphorylated.,similarity:Contains 1 C2 domai
Subcellular Location：Cell junction, synapse, postsynaptic density . Cell projection, dendritic spine . Cell projection, axon . Cell junction, synapse .
Expression：Brain,Epithelium,Platelet,Renal cell carcinoma,T-cell,
Immunogen：The antiserum was produced against synthesized peptide derived from human Bcr. AA range:331-380
Dilution：Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background：A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70481-Conjugate. Price: $485 / Size: 100μl.
：E20-70481-FITC$485 / 100μl：E20-70481-Biotin$485 / 100μl：E20-70481-HRP$485 / 100μl：E20-70481-AP$485 / 100μl：E20-70481-AF350$485 / 100μl：E20-70481-AF405M$485 / 100μl：E20-70481-AF488$485 / 100μl：E20-70481-AF514$485 / 100μl：E20-70481-AF532$485 / 100μl：E20-70481-AF555$485 / 100μl：E20-70481-AF568$485 / 100μl：E20-70481-AF405S$485 / 100μl：E20-70481-AF405L$485 / 100μl：E20-70481-AF546$485 / 100μl：E20-70481-AF594$485 / 100μl：E20-70481-AF610$485 / 100μl：E20-70481-AF635$485 / 100μl：E20-70481-AF647$485 / 100μl：E20-70481-AF680$485 / 100μl：E20-70481-AF700$485 / 100μl：E20-70481-AF750$485 / 100μl：E20-70481-AF790$485 / 100μl：E20-70481-APC$485 / 100μl：E20-70481-PE$485 / 100μl：E20-70481-Cy3$485 / 100μl：E20-70481-Cy5$485 / 100μl：E20-70481-Cy5.5$485 / 100μl：E20-70481-Cy7$485 / 100μl：E20-70481-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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