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BAP31 Polyclonal Antibody
： Human;Mouse;Rat;
： WB;ELISA
：Polyclonal, Rabbit,IgG
Price on request
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Gene Name：BCAP31
Product Information
Protein Name：B-cell receptor-associated protein 31
Human Gene Id：10134
Human Swiss Prot No：P51572
Mouse Gene Id：27061
Mouse Swiss Prot No：Q61335
Specificity：BAP31 Polyclonal Antibody detects endogenous levels of BAP31 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：BCAP31; BAP31; DXS1357E; B-cell receptor-associated protein 31; BCR-associated protein 31; Bap31; 6C6-AG tumor-associated antigen; Protein CDM; p28
Molecular Weight：27992DaObserved Band：28KD
Function：disease:Microdeletions in BCAP31 are involved in the contiguous ABCD1/DXS1375E deletion syndrome (CADDS) [MIM:300475]. Patients manifest profound neonatal hypotonia, subsequent failure to thrive, and cholestatic liver disease.,function:May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis.,PTM:Cleaved by CASP8 and other caspases.,similarity:Belongs to the BCAP29/BCAP31 family.,subcellular location:May shuttle between the ER and the intermediate compartment/cis-Golgi complex.,subunit:Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB.,tissue specificity:Ubiquitous.,
Subcellular Location：Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein . May shuttle between the ER and the intermediate compartment/cis-Golgi complex (PubMed:9396746). Associates with the mitochondria-associated endoplasmic reticulum membrane via interaction with TOMM40 (PubMed:31206022). .
Expression：Ubiquitous. Highly expressed in neurons and discrete endocrine cells.
Immunogen：The antiserum was produced against synthesized peptide derived from human BAP31. AA range:151-200
Dilution：Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background：This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012],
Conjugated Antibody
This product is also available conjugated. Format: ：E20-70451-Conjugate. Price: $485 / Size: 100μl.
：E20-70451-FITC$485 / 100μl：E20-70451-Biotin$485 / 100μl：E20-70451-HRP$485 / 100μl：E20-70451-AP$485 / 100μl：E20-70451-AF350$485 / 100μl：E20-70451-AF405M$485 / 100μl：E20-70451-AF488$485 / 100μl：E20-70451-AF514$485 / 100μl：E20-70451-AF532$485 / 100μl：E20-70451-AF555$485 / 100μl：E20-70451-AF568$485 / 100μl：E20-70451-AF405S$485 / 100μl：E20-70451-AF405L$485 / 100μl：E20-70451-AF546$485 / 100μl：E20-70451-AF594$485 / 100μl：E20-70451-AF610$485 / 100μl：E20-70451-AF635$485 / 100μl：E20-70451-AF647$485 / 100μl：E20-70451-AF680$485 / 100μl：E20-70451-AF700$485 / 100μl：E20-70451-AF750$485 / 100μl：E20-70451-AF790$485 / 100μl：E20-70451-APC$485 / 100μl：E20-70451-PE$485 / 100μl：E20-70451-Cy3$485 / 100μl：E20-70451-Cy5$485 / 100μl：E20-70451-Cy5.5$485 / 100μl：E20-70451-Cy7$485 / 100μl：E20-70451-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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